DNA: Supercoiling pushes molecular handcuffs along chromatin fibres

DNA: Supercoiling pushes molecular handcuffs along chromatin fibres

1:06 AM
As it squeezes down the chromatin fiber, the cohesin protein complex extrudes a growing loop of DNA -- a bit like the quick-lacing system of trail-running shoes. But what is powering the movement of the protein? A team of scientists has found that the driving force could be the supercoiling of upstream DNA. Their research is thereby adding a key piece to the puzzle of gene expression regulation.

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