Blood vessels-on-a-chip show anti-cancer drug effects in human cells

Researchers report new organ-on-a-chip technology to observe sprouting angiogenesis from a single blood vessel. VEGF stimulated new capillaries from the single vessel by activating NOTCH signaling, recapitulating biochemical events of the human angiogenesis. The chip also confirmed the effects of two FDA-approved anti-angiogenic drugs, demonstrating its applicability to drug discovery.

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